The 3 major sins in Islam are
shirk
Unjustly killing others
magic practice
And these are not only the major sins in Islam, but there are other major sins, including:
consuming Riba
Escaping and retreating from the battlefield
eating up an orphan's wealth
accusing a chaste women
The evidence for that is the saying of our Noble Prophet in the following hadith:
: “Avoid the seven destroyers.” They said: “O Allah’s Messenger! And what are they?” He replied: “Committing Shirk with Allah, magic, to kill someone that Allah has prohibited – except for just cause – consuming Riba (Usury), consuming the wealth or property of an orphan, to flee on the day of the march (to battle), and to slander the chaste, unaware, believing women.” (Bukhari)